(diamondback moth) hypothetical protein
AF-A0A811WGB1-F1-v4
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Predicted aligned error (PAE)
Click and drag a box on the PAE viewer to select regions of the structure and highlight them on the 3D viewer.
PAE data is useful for assessing inter-domain accuracy – go to Help section below for more information.
Start a structural similarity search to discover similar proteins.
AlphaFold database protein sequences clustered by the MMseqs2 algorithm (Steinegger M. and Soeding J., Nat. Commun. 9, 2018). Each cluster is comprised of sequences that fulfil two criteria: maintaining a maximum sequence identity of 50% and achieving a 90% bi-directional sequence overlap with the longest sequence of the cluster representative.
AFDB accession | Description | Species | Sequence length | Average pLDDT |
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AFDB accessionAF-B9WJY5-F1 | Description Elongation factor 1 alpha-like protein, putative Elongation factor 1 alpha-like protein, putative ... Elongation factor 1 alpha-like protein, putative | SpeciesCandida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841)... Candida dubliniensis (strain CD36 / ATCC MYA-646 / CBS 7987 / NCPF 3949 / NRRL Y-17841) | Sequence length 576 | Average pLDDT 83.81 |
AFDB accessionAF-A0A1E4SJ67-F1 | Description Tr-type G domain-containing protein Tr-type G domain-containing protein | SpeciesSuhomyces tanzawaensis NRRL Y-17324 Suhomyces tanzawaensis NRRL Y-17324 | Sequence length 532 | Average pLDDT 83.44 |
AFDB accessionAF-P32769-F1 | Description Elongation factor 1 alpha-like protein Elongation factor 1 alpha-like protein ... Elongation factor 1 alpha-like protein | SpeciesSaccharomyces cerevisiae (strain ATCC 204508 / S288c) Saccharomyces cerevisiae (strain ATCC 204508 / S288c)... Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Sequence length 611 | Average pLDDT 83.07 |
AFDB accessionAF-C4YT56-F1 | Description Tr-type G domain-containing protein Tr-type G domain-containing protein | SpeciesCandida albicans (strain WO-1) Candida albicans (strain WO-1) | Sequence length 581 | Average pLDDT 83 |
AFDB accessionAF-I2GX60-F1 | Description Tr-type G domain-containing protein Tr-type G domain-containing protein | SpeciesTetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 / UCD 77-7) Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 / UCD 77-7)... Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 / UCD 77-7) | Sequence length 600 | Average pLDDT 82.94 |
AFDB accessionAF-A0A1X2ILG5-F1 | Description p-loop containing nucleoside triphosphate hydrolase protein p-loop containing nucleoside triphosphate hydrolase protein ... p-loop containing nucleoside triphosphate hydrolase protein | SpeciesAbsidia repens Absidia repens | Sequence length 497 | Average pLDDT 82.88 |
AFDB accessionAF-A0A1X7R9I1-F1 | Description Similar to Saccharomyces cerevisiae YOR076C SKI7 Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation Similar to Saccharomyces cerevisiae YOR076C SKI7 Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation ... Similar to Saccharomyces cerevisiae YOR076C SKI7 Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation | SpeciesKazachstania saulgeensis Kazachstania saulgeensis | Sequence length 606 | Average pLDDT 82.69 |
AFDB accessionAF-A0A1Q2ZU39-F1 | Description Tr-type G domain-containing protein Tr-type G domain-containing protein | SpeciesZygosaccharomyces rouxii Zygosaccharomyces rouxii | Sequence length 570 | Average pLDDT 82.12 |
AFDB accessionAF-A0A4C2E2D2-F1 | Description Hsp70 suppressor, GTPase facilitates ribosomal subunit dissociation Hsp70 suppressor, GTPase facilitates ribosomal subunit dissociation ... Hsp70 suppressor, GTPase facilitates ribosomal subunit dissociation | SpeciesZygosaccharomyces mellis Zygosaccharomyces mellis | Sequence length 596 | Average pLDDT 82 |
AFDB accessionAF-Q6FTI4-F1 | Description Tr-type G domain-containing protein Tr-type G domain-containing protein | SpeciesCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)... Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) | Sequence length 594 | Average pLDDT 81.75 |
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How to interpret the Predicted Aligned Error
The Predicted Aligned Error (PAE) measures the confidence in the relative position of two residues within the predicted structure, providing insight into the reliability of relative position and orientations of different domains. Consider the human protein encoded by the gene GNE (Q9Y223). GNE has two distinct domains according to experimentally determined structures in the Protein Data Bank (PDBe-KB). Does AlphaFold confidently predict their relative positions? We can use the interactive Predicted Aligned Error (PAE) plot to answer this question. The PAE plot is not an inter-residue distance map or a contact map. Instead, the shade of green indicates the expected distance error in Ångströms (Å), ranging from 0 Å to an arbitrary cut-off of 31 Å. The colour at (x, y) corresponds to the expected distance error in the residue x’s position when the predicted and the true structures are aligned on residue y. The two low-error, dark green squares correspond to the two domains. By clicking and dragging, you can highlight these squares on the structure. If you want to remove the highlighting, click the cross icon. When selecting an off-diagonal region, the plot visually represents the relationship between the selected ranges on the sequence and structure. The x range corresponds to the selection for scored residues, highlighted in orange, while the y range of aligned residues is highlighted in emerald green. Let’s consider another inter-domain example, the human protein encoded by DIP2B (Q9P265). In this case, we have confidence in the relative position of scored residues around 1450 when aligned with residues around 850, suggesting a packing between the small central domains. Note that the PAE scores are asymmetrical, meaning there might be variations in PAE values between (x,y) and (y,x) positions. This is particularly relevant for loop regions with highly uncertain orientations, as seen on the DNA topoisomerase 3 (Q8T2T7).
A dark green tile corresponds to a good prediction (low error), whereas a light green tile indicates poor prediction (high error). For example, when aligning on residue 300:
The high PAE values across the whole inter-domain region indicate that for this particular protein, AlphaFold does not reliably predict the relative position of the domains.
Last updated
Last updated in AlphaFold DB version 2022-11-01, created with the AlphaFold Monomer v2.0 pipeline.
Licence and attribution
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If you make use of an AlphaFold prediction, please cite the following papers: Jumper, J et al. Highly accurate protein structure prediction with AlphaFold. Nature (2021).
Varadi, M et al. AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences. Nucleic Acids Research (2024).
If you use data from AlphaMissense in your work, please cite the following paper: Cheng, J et al. Accurate proteome-wide missense variant effect prediction with AlphaMissense. Science (2023).
AlphaFold Data Copyright (2022) DeepMind Technologies Limited.
AlphaMissense Copyright (2023) DeepMind Technologies Limited.
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