Downloads

The AlphaFold DB website currently provides bulk downloads for the 48 organisms listed below, as well as the majority of Swiss-Prot.

You can download a prediction for an individual UniProt accession by visiting the corresponding structure page (example: https://www.alphafold.ebi.ac.uk/entry/F4HVG8).

For downloading all predictions for a given species, use the download links below. Note that this option is only available on the desktop version of the site.

The uncompressed archive files (.tar) contain all the available compressed PDB and mmCIF files (.gz) for a reference proteome. In the case of proteins longer than 2700 amino acids (aa), AlphaFold provides 1400aa long, overlapping fragments. For example, Titin has predicted fragment structures named as Q8WZ42-F1 (residues 1–1400), Q8WZ42-F2 (residues 201–1600), etc. These fragments are currently only available for the human proteome in these proteome archive files, not on the website.

For downloading predictions for all the species in the tables below, visit the FTP site: https://ftp.ebi.ac.uk/pub/databases/alphafold

Compressed prediction files for model organism proteomes:

SpeciesCommon NameReference ProteomePredicted StructuresDownload
Arabidopsis thalianaArabidopsisUP000006548 27,434 Download (3,719 MB)
Caenorhabditis elegansNematode wormUP000001940 19,694 Download (2,655 MB)
Candida albicansC. albicansUP000000559 5,974 Download (985 MB)
Danio rerioZebrafishUP000000437 24,664 Download (4,224 MB)
Dictyostelium discoideumDictyosteliumUP000002195 12,622 Download (2,193 MB)
Drosophila melanogasterFruit flyUP000000803 13,458 Download (2,218 MB)
Escherichia coliE. coliUP000000625 4,363 Download (458 MB)
Glycine maxSoybeanUP000008827 55,799 Download (7,293 MB)
Homo sapiensHumanUP000005640 23,391 Download (4,877 MB)
Methanocaldococcus jannaschiiM. jannaschiiUP000000805 1,773 Download (174 MB)
Mus musculusMouseUP000000589 21,615 Download (3,619 MB)
Oryza sativaAsian riceUP000059680 43,649 Download (4,516 MB)
Rattus norvegicusRatUP000002494 21,270 Download (3,473 MB)
Saccharomyces cerevisiaeBudding yeastUP000002311 6,039 Download (979 MB)
Schizosaccharomyces pombeFission yeastUP000002485 5,128 Download (792 MB)
Zea maysMaizeUP000007305 39,299 Download (5,122 MB)

Compressed prediction files for global health proteomes:

SpeciesCommon NameReference ProteomePredicted StructuresDownload
Ajellomyces capsulatusAjellomyces capsulatusUP000001631 9,199 Download (1,366 MB)
Brugia malayiBrugia malayiUP000006672 8,743 Download (1,288 MB)
Campylobacter jejuniC. jejuniUP000000799 1,620 Download (175 MB)
Cladophialophora carrioniiCladophialophora carrioniiUP000094526 11,170 Download (1,734 MB)
Dracunculus medinensisDracunculus medinensisUP000274756 10,834 Download (1,366 MB)
Enterococcus faeciumEnterococcus faeciumUP000325664 2,823 Download (289 MB)
Fonsecaea pedrosoiFonsecaea pedrosoiUP000053029 12,509 Download (2,020 MB)
Haemophilus influenzaeH. influenzaeUP000000579 1,662 Download (176 MB)
Helicobacter pyloriH. pyloriUP000000429 1,538 Download (167 MB)
Klebsiella pneumoniaeK. pneumoniaeUP000007841 5,727 Download (561 MB)
Leishmania infantumL. infantumUP000008153 7,924 Download (1,511 MB)
Madurella mycetomatisMadurella mycetomatisUP000078237 9,561 Download (1,541 MB)
Mycobacterium lepraeMycobacterium lepraeUP000000806 1,602 Download (177 MB)
Mycobacterium tuberculosisM. tuberculosisUP000001584 3,988 Download (431 MB)
Mycobacterium ulceransMycobacterium ulceransUP000020681 9,033 Download (584 MB)
Neisseria gonorrhoeaeN. gonorrhoeaeUP000000535 2,106 Download (196 MB)
Nocardia brasiliensisNocardia brasiliensisUP000006304 8,372 Download (874 MB)
Onchocerca volvulusOnchocerca volvulusUP000024404 12,047 Download (1,624 MB)
Paracoccidioides lutziiParacoccidioides lutziiUP000002059 8,794 Download (1,298 MB)
Plasmodium falciparumP. falciparumUP000001450 5,187 Download (1,152 MB)
Pseudomonas aeruginosaP. aeruginosaUP000002438 5,556 Download (615 MB)
Salmonella typhimuriumS. typhimuriumUP000001014 4,526 Download (479 MB)
Schistosoma mansoniSchistosoma mansoniUP000008854 13,865 Download (2,549 MB)
Shigella dysenteriaeS. dysenteriaeUP000002716 3,893 Download (375 MB)
Sporothrix schenckiiSporothrix schenckiiUP000018087 8,652 Download (1,523 MB)
Staphylococcus aureusS. aureusUP000008816 2,888 Download (275 MB)
Streptococcus pneumoniaeS. pneumoniaeUP000000586 2,030 Download (203 MB)
Strongyloides stercoralisStrongyloides stercoralisUP000035681 12,613 Download (1,898 MB)
Trichuris trichiuraTrichuris trichiuraUP000030665 9,564 Download (1,365 MB)
Trypanosoma bruceiTrypanosoma bruceiUP000008524 8,491 Download (1,348 MB)
Trypanosoma cruziT. cruziUP000002296 19,036 Download (2,965 MB)
Wuchereria bancroftiWuchereria bancroftiUP000270924 12,721 Download (1,420 MB)

Compressed prediction files for Swiss-Prot:

File typePredicted StructuresDownload
Swiss-Prot (CIF files)542,378 Download (37,643 MB)
Swiss-Prot (PDB files)542,378 Download (26,935 MB)

MANE Select dataset:

File typePredicted StructuresDownload
Overlap with MANE17,334 Download (3,028 MB)

Full dataset download for AlphaFold Database - UniProt (214M):

The full dataset of all predictions is available at no cost and under a CC-BY-4.0 licence from Google Cloud Public Datasets. We've grouped this by single-species for ease of downloading subsets or all of the data. We suggest that you only download the full dataset if you need to process all the data with local computing resources (the size of the dataset is 23 TiB, ~1M tar files). Please see our guide for how to best download and query the data or reach out to alphafold@deepmind.com for further assistance.

Licence and attribution

Data is available for academic and commercial use, under a CC-BY-4.0 licence.

EMBL-EBI expects attribution (e.g. in publications, services or products) for any of its online services, databases or software in accordance with good scientific practice.

If you make use of an AlphaFold prediction, please cite the following papers:
Jumper, J et al. Highly accurate protein structure prediction with AlphaFold. Nature (2021).
Varadi, M et al. AlphaFold Protein Structure Database in 2024: providing structure coverage for over 214 million protein sequences. Nucleic Acids Research (2024).
If you use data from AlphaMissense in your work, please cite the following paper:
Cheng, J et al. Accurate proteome-wide missense variant effect prediction with AlphaMissense. Science (2023).

AlphaFold Data Copyright (2022) DeepMind Technologies Limited.
AlphaMissense Copyright (2023) DeepMind Technologies Limited.

Feedback and questions

If you want to share feedback on an AlphaFold structure prediction, please consider using the feedback buttons at the top of each structure page. If you have any questions that are not covered in the FAQs, please contact alphafold@deepmind.com. If you have feedback on the website or experience any bugs, please contact afdbhelp@ebi.ac.uk.

Disclaimer

The AlphaFold and AlphaMissense Data and other information provided on this site contain predictions with varying levels of confidence, is for theoretical modelling only and caution should be exercised in its use. It is provided 'as-is' without any warranty of any kind, whether expressed or implied. For clarity, no warranty is given that use of the information shall not infringe the rights of any third party. The information is not intended to be a substitute for professional medical advice, diagnosis, or treatment, and does not constitute medical or other professional advice. The AlphaFold and AlphaMissense Data have not been validated for, and are not approved for, any clinical use.

Use of the AlphaFold Protein Structure Database is subject to EMBL-EBI Terms of Use.